Non-invasive analysis of the likelihood that TLE (Temporal Lobe Epilepsy) patients will be seizure-free after surgery.
A unique program integrated into the NeuroQ™ application.
Conventional visual analysis of brain F18-PET FDG scans is useful for predicting post-surgical improvement for TLE patients, but prognostic value for identifying patients who will achieve seizure-free status is considerably lower.
EQuAL is useful for assessing maximal temporal asymmetry over a
specified proportion of the temporal lobe which may help to predict whether patients will likely be free of seizueres during the years after neurosurgical resection of epileptogenic tissue.
EQuAL (Extent-specified Quantified Asymmetry-of-Lobe analysis) is a unique tool integrated into NeuroQ, based on work by Lin et. al from the Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA Los Angeles and published in the Journal of Nuclear Medicine.
Tina W. Lin, Michelle A. Kung de Aburto, Magnus Dahlbom, Lynn L. Huang, Michael M. Marvi, Michael Tang, Johannes Czernin, Michael E. Phelps, and Daniel H.S. Silverman. Predicting Seizure-Free Status for Temporal Lobe Epilepsy Patients Undergoing Surgery: Prognostic Value of Quantifying Maximal Metabolic Asymmetry Extending over a Specified Proportion of the Temporal Lobe. J Nucl Med. 2007 48(5): 776-782.